Formulation, Characterization and In - Vitro Drug Release Studies of Gastrointestinal Mucoadhesive Patches Bearing Anticancer Drug - Delivery for Colon Cancer

Abstract

In an attempt to prolong the release and improve the absorption of the drug, we developed gastrointestinal mucoadhesive patches containing the anticancer drug - 6-mercaptopurine. We observed that all formulations prepared for the fabrication of gastrointestinal mucoadhesive patches were smooth, translucent, and flexible in nature. There was a regular distribution of weights and thicknesses across all formulations of the formulation. Furthermore, on these Gastrointestinal Mucoadhesive Patches, the following parameters were also measured: pH, folding endurance, swelling percentage (%S) and in vitro disintegration time. The release profiles of Gastrointestinal Mucoadhesive Patches have been shown to be enhanced in vitro, and the release patterns are pH- dependent, which suggests they provide faster absorption and increased reach. The method of solvent cast technology has proven to be an efficient method of preparing the patch for administering 6- mercaptopurine to the gastrointestinal tract through the application of gastrointestinal mucoadhesive patches.