Analytical Methods and Permeation Mechanism of Eletriptan

Abstract

One of the most popular complaints is headache, specifically migraine. Migraine is a chronic, incapacitating neurovascular situation that causes severe headache the episodes, autonomic nervous system dysfunction, and, in rare instances, an aura with neurologic symptoms. It affects a significant portion of the world's population, with females (15-18%) having a higher incidence than males (6%). Based to a recent WHO evaluation, severe migraine, along with quadriplegia, psychosis, and dementia, is one of the most devastating chronic diseases. There are now two hypotheses clarifying the existence of migraine headache: vascular theory and neural theory. The main goal of migraine therapy is to identify and reduce etiologic or aggravated causes. Furthermore, preventive and abortive therapy may be used to prevent, shorten the length of, and treat symptomologies. As a result, for the administration of an anti-migraine medical care, an approach of delivering the drug into the bloodstream via parenteral route would be ideal. However, the resulting discomfort, danger of infection, difficult administered methods, and the possibility for low patient compliance make such parenteral administration unpleasant.