Formulation and Characterization of Enteric Coated Tablets of Zingiber Officinale Extract for Antimigraine Activity

Abstract

Purpose-For the purpose of treating the aura phase of migraines, an enteric-coated zingiber officinale (Ginger) extract tablet formulation, and evaluation was attempted in the current study.

Methods-To achieve this goal, core ginger extract tablets were prepared by using the direct compression method.  Based on results of factors drug release and disintegration time from design of experiment software, optimization of batch was done. Optimized batch used for formulation and evaluation of enteric coated tablet by dipping method. Eudragit L 100, PEG, and acetone was used for the coating of the tablet. Drug release and disintegration time for the first 2 Hr in 0.1 N HCL and then 1 Hr in 6.8 pH phosphate buffer were performed for the prepared coating tablet.

Result-All Prepared tablets are evaluated for their pre-compression and post-compression characters. Optimized formulation shows no drug release at first 2 hrs in gastric fluid and shows 86.78% drug release in pH 6.8.

Conclusion- Ginger Extract is an acid sensitive medication and it is protected by enteric coating to give better therapeutic results.