In Vitro Evaluation of Polyherbal Cream as a Promising Therapeutic Approach for Psoriasis: Assessing Anti-inflammatory and Anti-Fungal activity

Abstract

The aim of this study was to develop and assess the effectiveness of a polyherbal cream containing extracts of Terminalia chebula, Cassia tora, Ocimum sanctum, and Cynodon dactylon for the treatment of psoriasis, a chronic autoimmune skin condition characterized by scaly patches on the skin. Given the limitations of traditional treatments, herbal medicines have gained popularity as alternative or complementary therapies for psoriasis. The physical and chemical characteristics of the polyherbal cream were evaluated after formulation using a standardized procedure. The study findings revealed significant anti-inflammatory and antioxidant properties of the polyherbal cream, both of which are crucial for the successful management of psoriasis. Furthermore, in vitro studies using the protein denaturation method and in vitro cell viability assay and anti-microbial study demonstrated the cream's anti-inflammatory activity. These results suggest that the polyherbal cream containing Terminalia chebula, Cassia tora, Ocimum sanctum, and Cynodon dactylon extracts may serve as an effective alternative or complementary therapy for psoriasis. However, further clinical trials are necessary to validate the long-term safety and efficacy of the cream.