Formulation, Evaluation and Comparison Study of Sublingual Tablets of Flubendazole with Solid Dispersed Sublingual Tablets of Flubendazole for Prophylaxis of Filariasis

Abstract

This investigation is concerned with formulation of oral dosage form for prophylaxis of filariasis with sublingual tablets.

A macrofilaricide such as Flubendazole would be extremely helpful in the effort to eradicate human filariases. The need for alternative pharmacological techniques to enhance the systemic bioavailability of Flubendazole and its metabolites has become more urgent as a result of significant injection site reactions being observed in humans after parenteral Flubendazole treatment. Oral mucosal delivery of drugs promotes rapid absorption and high bioavailability, with a subsequent immediate onset of pharmacological effect along with patient convenience and compliance.

The present study, aims to develop sublingual tablets of Flubendazole. Different concentrations of superdisintegrant Crospovidone were added. Mannitol was added in appropriate ratios for taste masking.

The study involved formulation of solid dispersion system of Flubendazole to enhance soubility and hence bioavailability. Drug content and in vitro studies were carried out on the formulation. All formulation of pure drug and solid dispersion system were compressed by direct compression method. These tablets were evaluated as final dosage form for drug content and in vitro release profile.

A comparative study of all dosage form was carried out. In vitro release studies were carried  out mimicking in vivo conditions in the sublingual region for dissolution. It was seen that solid dispersion drug delivery system formulation SD3 showed maximum release of 93.56% after 18 minutes as compared to F3 formulation.

Thus it was concluded that solid dispersion delivery system of Flubendazole can be a better option for the prophylaxis of filariasis.