Design, Synthesize and Characterization the Quinazoline Derivatives as Antitubercular Agent

Abstract

An efficient direct amination of quinazolin-4(3H)-ones using N,N-dimethylformamide as a nitrogen source is described that affords the corresponding 4-(dimethylamino)quinazolines in high yields. This transformation proceeds through efficient 4-toluenesulfonyl chloride mediated C–OH bond activation at room temperature. These Synthesized 4 compounds were confirmed through spectral characterization using IR, NMR, MASS Spectroscopy. The result showed significance for these compounds antitubercular activity compared with Pyrazinamide as a standard drug.